Overview & Mechanism

Melanotan II is a synthetic analogue of α-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective agonist of melanocortin receptors, primarily MC1R, while also interacting with MC3R, MC4R, and MC5R. Activation of these receptors stimulates melanin production in melanocytes and has made Melanotan II a widely investigated compound in pigmentation biology, photoprotection, melanogenesis, and melanocortin receptor signaling. It has also been explored in research involving appetite regulation and sexual physiology due to its broader receptor activity.

Key Research Focus Areas:

Melanogenesis Research: Extensively investigated for stimulating melanin synthesis through activation of the melanocortin-1 receptor (MC1R).

Pigmentation Biology: Studied for its effects on skin pigmentation, UV responsiveness, and melanocyte physiology in experimental models.

Photoprotection Research: Evaluated for its potential role in increasing endogenous melanin production as a mechanism of photoprotection.

Melanocortin Receptor Pharmacology: Explored for its activity across multiple melanocortin receptors involved in pigmentation, appetite regulation, and neuroendocrine signaling.

Technical Profile & Validation

This lyophilized peptide is manufactured to an exceptional research standard exceeding 99% purity. Melanotan II demonstrates high receptor affinity and excellent molecular stability, making it a valuable research compound for laboratory investigations involving melanocortin receptor pharmacology, pigmentation biology, and peptide signaling.

Scientific Reference:
Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review
https://pubmed.ncbi.nlm.nih.gov/28266027/

Technical Specifications

⚠️ Important Reconstitution Notice Before initiation of the reconstitution protocol, ensure that both the lyophilized peptide vial and the bacteriostatic mixing water have stabilized at room temperature (20°C - 22°C). This step supports proper molecular dissolution and prevents potential destabilization of the micropeptide chain. Note: Bacteriostatic water is distributed separately.

Legal Disclaimer

All compounds and products featured on this platform are synthesized and distributed strictly for laboratory research, in vitro evaluation, and academic studies. These substances are under no circumstances intended, approved, or cleared for human or animal consumption, nor should they be classified as medical products, therapies, drugs, or food supplements.

By executing a purchase, the buyer explicitly assumes all associated biochemical risks and guarantees handling by qualified personnel within a controlled environment. The manufacturer, distributor, and seller maintain a policy of zero liability for any misuse, unauthorized administration, or unverified secondary outcomes. Finalizing your order constitutes full compliance with our academic research terms and conditions.