Overview & Mechanism

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic adenosine analogue that functions as a potent activator of AMP-activated protein kinase (AMPK), the body's primary cellular energy sensor. Following intracellular conversion to ZMP, an AMP analogue, AICAR activates AMPK signaling, promoting glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and metabolic adaptation. It has become one of the most extensively studied research compounds in exercise physiology, metabolic regulation, and mitochondrial biology.

Key Research Focus Areas:

AMPK Activation: Extensively investigated for selectively activating AMP-activated protein kinase, the master regulator of cellular energy homeostasis.

Mitochondrial Function: Studied for promoting mitochondrial biogenesis and improving cellular bioenergetic efficiency during metabolic stress.

Metabolic Regulation: Evaluated for enhancing glucose uptake, increasing fatty acid oxidation, and supporting metabolic flexibility.

Exercise & Endurance Research: Explored for its influence on skeletal muscle metabolism, oxidative capacity, and endurance adaptation in preclinical research models.

Technical Profile & Validation

This research-grade powder is manufactured to an exceptional standard exceeding 99% purity. AICAR demonstrates excellent molecular stability and reproducibility, making it a valuable compound for laboratory investigations involving AMPK signaling, mitochondrial biology, metabolism, and exercise physiology.

Scientific Reference:
AMPK and PPARδ Agonists Are Exercise Mimetics
https://pubmed.ncbi.nlm.nih.gov/18674809/

Technical Specifications

⚠️ Important Reconstitution Notice Before initiation of the reconstitution protocol, ensure that both the lyophilized peptide vial and the bacteriostatic mixing water have stabilized at room temperature (20°C - 22°C). This step supports proper molecular dissolution and prevents potential destabilization of the micropeptide chain. Note: Bacteriostatic water is distributed separately.

Legal Disclaimer

All compounds and products featured on this platform are synthesized and distributed strictly for laboratory research, in vitro evaluation, and academic studies. These substances are under no circumstances intended, approved, or cleared for human or animal consumption, nor should they be classified as medical products, therapies, drugs, or food supplements.

By executing a purchase, the buyer explicitly assumes all associated biochemical risks and guarantees handling by qualified personnel within a controlled environment. The manufacturer, distributor, and seller maintain a policy of zero liability for any misuse, unauthorized administration, or unverified secondary outcomes. Finalizing your order constitutes full compliance with our academic research terms and conditions.