Overview & Mechanism

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism, methylation pathways, and adipocyte function. By selectively inhibiting NNMT activity, 5-Amino-1MQ has been extensively investigated for its potential to preserve intracellular NAD⁺ levels, enhance metabolic efficiency, and regulate fat storage in preclinical research models.

Key Research Focus Areas:

Metabolic Regulation: Extensively investigated for modulating cellular energy metabolism through selective inhibition of NNMT activity.

NAD⁺ Preservation: Studied for its ability to increase intracellular NAD⁺ availability by reducing nicotinamide methylation, supporting mitochondrial function and cellular bioenergetics.

Body Composition Research: Evaluated for its effects on adipocyte metabolism, lipogenesis, and fat mass reduction in preclinical obesity models.

Healthy Aging & Cellular Metabolism: Explored for its role in supporting metabolic flexibility, mitochondrial efficiency, and age-related changes in cellular energy homeostasis.

Technical Profile & Validation

This research-grade powder is manufactured to an exceptional standard exceeding 99% purity. 5-Amino-1MQ demonstrates high selectivity for the NNMT enzyme with minimal off-target activity, making it a valuable compound for laboratory investigations into metabolism, obesity, and NAD⁺ biology.

Scientific Reference:
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
https://pubmed.ncbi.nlm.nih.gov/29155147/

Technical Specifications

⚠️ Important Reconstitution Notice Before initiation of the reconstitution protocol, ensure that both the lyophilized peptide vial and the bacteriostatic mixing water have stabilized at room temperature (20°C - 22°C). This step supports proper molecular dissolution and prevents potential destabilization of the micropeptide chain. Note: Bacteriostatic water is distributed separately.

Legal Disclaimer

All compounds and products featured on this platform are synthesized and distributed strictly for laboratory research, in vitro evaluation, and academic studies. These substances are under no circumstances intended, approved, or cleared for human or animal consumption, nor should they be classified as medical products, therapies, drugs, or food supplements.

By executing a purchase, the buyer explicitly assumes all associated biochemical risks and guarantees handling by qualified personnel within a controlled environment. The manufacturer, distributor, and seller maintain a policy of zero liability for any misuse, unauthorized administration, or unverified secondary outcomes. Finalizing your order constitutes full compliance with our academic research terms and conditions.